Fig. 4

Impact from number of biological replicates on differential RNA methylation analysis. The performance of all 7 methods tested increases as the number of biological replicates increases, suggesting biological replicates are still essential for the proposed small-sample inference approach. QNB method outperforms competing approaches on datasets with 2, 3, 4 and 6 biological replicates, succeeded by DRME, DSS and ChIPComp