Fig. 1
From: Detecting large deletions at base pair level by combining split read and paired read data
Visual depiction of Pegasus algorithm. The images show read pairs that are mapped to a reference genome, where the blue read pairs span a deletion event. (Top panel) Soft-clipped reads (pink and green subreads) are initially unaligned since they fall within the deleted region. Pegasus first clusters discordant read pairs that may indicate a deletion. It then maps the clipped subreads back to the reference using BLAT (middle panel). The subreads align to each side of the deletion event. The coordinate locations with the most aligned subreads are the predicted deletion breakpoints (bottom panel)