Skip to main content

Table 4 Putative driver gene sets discovered by QuaDMutEx

From: QuaDMutEx: quadratic driver mutation explorer

Putative driver genes

Estimated

discovered by QuaDMutEx

p-value

GBM: Glioblastoma multiforme

  CDKN2B (43) TSFM (16) RB1 (10) ERBB2 (7) ITGB3 TRIM2 WEE1 CHD5 MARK4 CES3 SHH IQGAP1 (1)

0.023

OV: Ovarian cancer

  TP53 (299) KRAS (2) RNASE3 (1)

0.010

LUNG: Lung Adenocarcinoma

  KRAS (60) STK11 (34) EGFR (30) EPHB1 (4) MAP3K3 (3) ABL1 PAK6 MAST1 CYSLTR2 RPS6KA6 FES (2) BAX PIK3C2B RANBP9 RPSA (1)

0.036

BRCA: Breast Invasive Carcinoma

  TP53 (194) PIK3CA (138) GATA3 (80) NBPF1 (27) CTCF (18) ATM (16) FOXA1 (15) TMEM132C (6) CABIN1 SRGAP2 KIAA1310 (5) CASP8AP2 TSNARE1 (4) ADCY1 PITX2 PSG11 (3) ANKRD34B KRT14 MSI1 TWISTNB (2)

0.002

  1. For each gene, in parentheses, we provide the number of patients in the dataset that harbored a mutation in that gene. Genes in bold are present int the DriverDBv2 [7] database of previously discovered cancer drivers