Tools | Algorithm | GC content | Pseudoknot |
---|---|---|---|
RNAinverse [11] | Local search | No | No |
RNA-SSD [12] | Stochastic local search | No | No |
 | and structure decomposition |  |  |
INFO-RNA [13] | Dynamic programming | No | No |
 | and local search |  |  |
NUPACK [14] | Minimization of ensemble | No | No |
 | defect and structure |  |  |
 | decomposition |  |  |
RNAexinv [35] | Simulated annealing | No | No |
Frnakenstein [15] | Genetic algorithm | No | No |
EteRNABot [36] | Downhill simplex algorithm | No | No |
ERD [16] | Evolutionary algorithm | No | No |
 | and structure |  |  |
 | decomposition |  |  |
RNAifold [19] | Constraint programming | Yes | No |
 | and structure |  |  |
 | decomposition |  |  |
IncaRNAtion [18] | Weighted sampling | Yes | No |
 | algorithm and |  |  |
 | local search |  |  |
MODENA [17] | Multi-objective | Yes | Yes |
 | genetic algorithm |  |  |
Ant colony optimization | Yes | Yes | |
Enzymer [37] | Adaptive weighted | No | Yes |
 | sampling |  |  |
MCTS-RNA | Monte Carlo tree search | Yes | Yes |