Fig. 5
From: DMRfinder: efficiently identifying differentially methylated regions from MethylC-seq data
Comparison of DMR identification by DMRfinder and DSS. a A region on chromosome 20 that covers seven CpG sites. The methylation levels of IMR90 at all seven sites are higher than those of H1 (circles), but on an individual basis, none of the sites showed significant differential methylation (squares), using the threshold of DSS (p-value <Â 1e-5). With DMRfinder, the sites were clustered together, and the weighted methylation fractions (dashed lines) were determined to be statistically significantly different. b DMRs identified by DSS and DMRfinder in a region on chromosome 13. The DMR called by DSS spanned four CpG sites and more than 700Â bp (purple box). With DMRfinder, the CpG sites were grouped into two clusters, both of which were classified as DMRs (green boxes). c A DMR identified uniquely by DSS on chromosome 7. Two of the CpG sites in the DMR were hypermethylated in IMR90 cells, and two were hypomethylated. For the entire region, DMRfinder calculated a small methylation difference and did not call a DMR