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Fig. 1 | BMC Bioinformatics

Fig. 1

From: DBNorm: normalizing high-density oligonucleotide microarray data based on distributions

Fig. 1

An example application of DBNorm. Probesets from data source 1 (top left) and probesets from data source 2 (bottom left) are visualised with PCA and show platform specific variation. DBNorm takes histograms of probe sets from each data source (second column) and fits a curve to the shape (column 3). The formula (middle column 3) normalises data source 1 to take the shape of data source 2. PCA visualisation of the combined dataset (bottom right) shows reduction in platform specific variation

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