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Table 4 Relationship of the top 6 expressed genes with breast cancer

From: Integration of RNA-Seq data with heterogeneous microarray data for breast cancer profiling

Gene symbol

Gene name

Relationship between protein and breast cancer


Secreted frizzled-related protein 1

Inhibition of SFRP1 increases the proliferation, migration and invasion of breast cancer cells. SFRP1 exerted this function by activating Wnt/ β-catenin signaling pathway in breast carcinogenesis [42, 43].


Glutathione S-transferase mu 3

GSTM3 is suggested as an important modifier that impacts on individual susceptibility to develop breast cancer among premenopausal women [44]. High expression of GSTM3 is related to protective genotypes against breast cancer


Gulfotransferase family 1E member 1

SULT1E1 is an enzyme that catalyzes the sulfation of active 17 β-estradiol into inactive form. SULT1E1 is highly expressed in normal mammary epithelial cells and rarely expressed in breast cancer cells. However, its over-expression in breast carcinomas is considered to retard tumor cell growth by arresting cell cycles and inducing apoptosis and may thus improve the prognosis of breast cancer [45, 46].



MB plays a functional role in breast cancer progression by promoting the growth of fully oxygenated cells through the control of fatty acid homeostasis and lipogenesis [47, 48]. MB is dose-dependent downregulated by 17 β-estradiol in breast cancer cells [49].


Tripartite motif containing 29

TRIM29 is considered a breast cancer tumor suppressor. Low TRIM29 expression in breast cancer is associated with more aggressive tumor features. Suppression of the oncogenic transcription factor TWIST1 expression is one mechanism suggested by which TRIM29 functions as a suppressor of breast cancer development [50].


V-set and transmembrane domain containing 2 like

Although VSTM2L is detected in breast cancer tissues, to date there are no relation between its expression and breast cancer development in the current literature.