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Fig. 2 | BMC Bioinformatics

Fig. 2

From: ClusterTAD: an unsupervised machine learning approach to detecting topologically associated domains of chromosomes from Hi-C data

Fig. 2

Illustration of the topologically associated domains. a Illustration of the basic elements related to TAD: domain, border, boundary, and gap. A domain is a TAD. A boundary is the chromosomal region between two consecutive TADs. The border marks the start/end of a domain. A gap is a point with no interaction in the contact matrix. b The calculation of TAD quality score. Two adjacent TADs are denoted as i and j. The area between TADs i and j that has few interactions is labeled as E. The intra(i) is the average contact frequency within a TAD (e.g. the area marked i). The inter(i, j) is the average contact frequency of the area marked as E. The difference of the two is the quality of TAD i

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