Fig. 1

a The anchored network parameter dialog box. iPoint can be selected as an alternative “sub-algorithm” in the “Advanced” section, while anchor prediction and transcription factor prediction are available as additional options. b The network solution (left panel) and the network solution with “predict transcription factors” (right panel). The “predict transcription factors” reveals key transcription factors on a breast cancer dataset such as HIF1α and PARP1. The network shows the predicted pathways connecting the anchors (green) via connecting proteins (pink) and predicted transcription factors (salmon) to the terminals (red). Undirected edges correspond to PPIs and directed edges depict PDIs