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Table 1 Number of predicted clashes by amino acid types in PDB structures that tolerate substitutions

From: PON-SC – program for identifying steric clashes caused by amino acid substitutions

  PON-SC number PON-SC (%) SCWRL+ Probe number SCWRL+ Probe (%) Botha number Both (%) Totalb
Alanine 0 0 0 0 0 0 1165
Arginine 86 25.52 11 3.26 15 4.45 337
Asparagine 37 8.22 112 24.89 7 1.56 450
Aspartic acid 38 8.35 125 27.47 13 2.85 455
Cysteine 0 0 4 1.316 0 0 304
Glutamic acid 92 18.70 42 8.54 42 8.54 492
Glutamine 42 15 31 11.07 22 7.86 280
Glycine 0 0 0 0 0 0 393
Histidine 74 21.70 45 13.20 38 11.14 341
Isoleucine 94 33.45 38 13.52 42 14.95 281
Leucine 96 25.26 39 10.26 27 7.11 380
Lysine 53 19.41 6 2.20 5 1.83 273
Methionine 93 32.63 11 3.86 10 3.51 285
Phenylalanine 86 18.86 118 25.88 95 20.83 456
Proline 90 76.92 0 0 0 0 117
Serine 5 0.89 4 0.71 0 0 561
Threonine 78 24.68 30 9.49 28 8.86 316
Tryptophan 54 29.19 29 15.68 58 31.35 185
Tyrosine 110 30.05 76 20.77 71 19.40 366
Valine 122 34.08 41 11.45 42 11.73 358
  1. aDoes not include cases listed in PON-SC and SCWRL+Probe columns. bTotal number of substitutions in the dataset.