BMC Bioinformatics

Table 2 Validation of the method performance

From: PON-SC – program for identifying steric clashes caused by amino acid substitutions

Study	TP	FP	TN	FN	Total	NPV	PPV	Sensitivity	Specificity	Accuracy	MCC
CD40LG	9	1	18	4	32	0.75	093	0.69	0.95	0.82	0.66
SH2	13	25	46	15	99	0.54	0.57	0.46	0.65	0.55	0.11
ELANE	16	1	2	4	23	0.77	0.70	0.80	0.65	0.73	0.46
TP53	27	19	102	16	164	0.69	0.80	0.63	0.84	0.74	0.48
CANCER	7	5	16	3	31	0.72	0.75	0.71	0.76	0.74	0.47
Total/Average	72	51	184	42	349	0.69	0.74	0.66	0.77	0.71	0.43

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ISSN: 1471-2105

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