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Table 2 Validation of the method performance

From: PON-SC – program for identifying steric clashes caused by amino acid substitutions

Study TP FP TN FN Total NPV PPV Sensitivity Specificity Accuracy MCC
CD40LG 9 1 18 4 32 0.75 093 0.69 0.95 0.82 0.66
SH2 13 25 46 15 99 0.54 0.57 0.46 0.65 0.55 0.11
ELANE 16 1 2 4 23 0.77 0.70 0.80 0.65 0.73 0.46
TP53 27 19 102 16 164 0.69 0.80 0.63 0.84 0.74 0.48
CANCER 7 5 16 3 31 0.72 0.75 0.71 0.76 0.74 0.47
Total/Average 72 51 184 42 349 0.69 0.74 0.66 0.77 0.71 0.43