Fig. 2
From: Pharmacophore anchor models of flaviviral NS3 proteases lead to drug repurposing for DENV infection
The flaviviral NS3 protease Core pharmacophore anchor (CPA) model. a Anchor alignment among the PA models of four virus NS3 proteases (HCV, DENV, WNV and JEV) identified core anchors (pink dotted outline). b The CPA model showing five core anchors (CEH1, CH3, CH7, CV1, and CV3) include NS3 proteases from HCV (cyan), DENV (green), WNV (wheat pink), and JEV (purple) with active site subsites (pink). c Anchor features of core anchors: anchor types, anchor residues and moiety preferences. (CEH1: orange; CH3 and CH7: green; CV1 and CV3: grey)