Fig. 1

Graphical representation of the NetLogo model. The flow is the following: i) Hpv let Kcs change their color and state: from pink/healthy to white/infected; ii) DC processes Hpv antigen becoming MhcII-presenting DC and produces IFN; iii) IFN acts on infected Kcs bringing them back to healthy state; iv) MhcII-presenting Dc activates B cell; v) B cells become both memory B cells and plasma B cells; vi) Memory B cells are stimulated by Hpv to differentiate into IgG-producing plasma B cells; vii) Plasma B cells release IgG; viii) IgG catches and kills Hpv; ix) NK kills infected Kcs; x) CTL kills infected Kcs; xi) Treg downregulates CTLs