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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Combining agent based-models and virtual screening techniques to predict the best citrus-derived vaccine adjuvants against human papilloma virus

Fig. 3

In silico results of the best vaccination protocols obtained by our computational model. Antibodies levels are expressed in arbitrary units while time is expressed in hours. Line A shows IgG levels detected after the administration of 10 μg of Neohesperidin at day 0, followed by a second injection of 1 μg of Neohesperidin at day 14, corresponding to the “t” in silico experiment of Table 1. Line B, IgG levels detected after the administration of 10 μg of Neohesperidin at day 0, followed by a second injection of 1 μg of Neohesperidin at day 21. This vaccination protocol corresponds to the “m” in silico experiment of Table 1. Line C depicts IgG levels recorded after the administration of 10 μg of Neohesperidin at day 0, followed by a second injection of 1 μg of Neohesperidin at day 28, corresponding to the “n” in silico experiment of Table 1. Finally, line D shows IgG titers recorded after the administration of 10 μg of Neohesperidin at day 0, followed by a second injection of 1 μg of Naringenin at day 28. This vaccination protocol corresponds to the “l” in silico experiment of Table 1. CTRL line corresponds to the control case i.e., HPV16L1 only, administered at time 0 and 14

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