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Fig. 3 | BMC Bioinformatics

Fig. 3

From: Cell ontology in an age of data-driven cell classification

Fig. 3

Linking projection neurons to exemplars derived from clustering. Panel a: Cluster of neurons with similar morphology from unsupervised clustering of >16,000 co-registered single neuron images (Costa et al. [3]) Panel b: VGlut-F-400462 (Chiang et al., [29]) is the exemplar (most typical neuron) from the cluster in panel A is shown in yellow. It has arborizes in the antennal lobe (AL; red), calyx of adult mushroom body (MB calyx; purple), lateral horn in (LH; blue). Image generated in VFB 2.0 alpha (unpublished). Panel c: OWL Axiomatization defining ‘adult antennal lobe projection neuron DL2 adPN’, which the cluster in panel a was manually mapped to. A minimal-commitment equivalent class axiom defines the class my lineage and innervated glomerulus. Innervation of the MB calyx and LH are recorded in subclass axioms. The axiom in blue links this class to the exemplar of the cluster, providing a standard reference for morphology and a substrate for future NBLAST queries of co-registered neurons

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