Table 1 Analysis of methylation regions using current methods (40 samples)
From: Redundancy analysis allows improved detection of methylation changes in large genomic regions
Region size | Sim. DMP % | Diff. Means | CpGs in Bumps (%) | R2 (sd) | |
|---|---|---|---|---|---|
Target region | Random region | ||||
500Kb | 30 | 0.3 | 28.10 | 0.647 (0.109) | 0.026 (0.010) |
30 | 0.1 | 3.23 | 0.430 (0.098) | 0.025 (0.010) | |
30 | 0.05 | 0.21 | 0.346 (0.124) | 0.026 (0.010) | |
10 | 0.3 | 9.16 | 0.442 (0.075) | 0.024 (0.008) | |
10 | 0.1 | 0.45 | 0.277 (0.101) | 0.026 (0.009) | |
10 | 0.05 | 0.02 | 0.205 (0.135) | 0.025 (0.008) | |
300Kb | 30 | 0.3 | 28.10 | 0.674 (0.113) | 0.026 (0.013) |
30 | 0.1 | 3.76 | 0.417 (0.083) | 0.025 (0.008) | |
30 | 0.05 | 0.11 | 0.332 (0.127) | 0.026 (0.011) | |
10 | 0.3 | 8.80 | 0.446 (0.084) | 0.026 (0.009) | |
10 | 0.1 | 0.30 | 0.278 (0.100) | 0.026 (0.010) | |
10 | 0.05 | 0.02 | 0.178 (0.112) | 0.026 (0.011) | |
100Kb | 30 | 0.3 | 27.80 | 0.682 (0.125) | 0.025 (0.011) |
30 | 0.1 | 3.58 | 0.430 (0.103) | 0.026 (0.011) | |
30 | 0.05 | 0.15 | 0.317 (0.122) | 0.026 (0.011) | |
10 | 0.3 | 8.72 | 0.453 (0.104) | 0.027 (0.014) | |
10 | 0.1 | 0.35 | 0.249 (0.112) | 0.025 (0.010) | |
10 | 0.05 | 0.00 | 0.171 (0.123) | 0.025 (0.011) | |
50Kb | 30 | 0.3 | 27.70 | 0.705 (0.120) | 0.027 (0.012) |
30 | 0.1 | 3.93 | 0.426 (0.096) | 0.027 (0.012) | |
30 | 0.05 | 0.10 | 0.308 (0.096) | 0.026 (0.010) | |
10 | 0.3 | 8.60 | 0.442 (0.120) | 0.028 (0.017) | |
10 | 0.1 | 0.42 | 0.250 (0.100) | 0.026 (0.013) | |
10 | 0.05 | 0.03 | 0.149 (0.090) | 0.028 (0.015) | |