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Table 1 Characteristics of available meta-analysis software

From: MetaGenyo: a web tool for meta-analysis of genetic association studies

  STATA SPSS MIX MetaEasy meta rmeta metafor MetaGenyo
USABILITY
Availability Commercial Commercial Commerciala Freeb Free Free Free Free
Web-based No No No No No No No Yes
Operating system Windows, Mac OS, Linux Windows, Mac OS, Linux Windows Windows Windows, Mac OS, Linux Windows, Mac OS, Linux Windows, Mac OS, Linux Anyc
Guided workflow No No No No No No No Yes
Programming knowledge Yesd Yesd No No R language R language R language No
FUNCTIONALITIES
Specific for GAS meta-analysis No No No No No No No Yes
HWE testing Yes No No No No No No Yes
Heterogeneity assessment Yes Yes Yes Yes Yes Yes Yes Yes
Random/Fixed effect models Yes Yes Yes Yes Yes Yes Yes Yes
Forest plot Yes Yes Yes Yes Yes Yes Yes Yes
Automatic testing of genetic models No No No No No No No Yes
Publication bias Yes Yes Yes No Yes Yes Yes Yes
Subgroup analysis Yes No Yes No Yes No Yes Yes
Robustness analysis Yes No Yes No Yes No Yes Yes
P-value correction for multiple testing Yes Yes No No No No No Yes
  1. aThere is a MIX free version with reduced capabilities. bMetaEasy is free, but it depends on the proprietary software Microsoft Excel. cMetaGenyo is accessed through an internet browser, so there are no limitations regarding the operating system used to access it. dAlthough STATA and SPSS are command-based software, there are graphical user interfaces (GUIs) available which permits replacing scripting by user-friendly interactive commands