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Table 1 Original genetic signals (indicated by p values) are absent in the simulated data

From: Simulating autosomal genotypes with realistic linkage disequilibrium and a spiked-in genetic effect

SNP Original GWASa Type I error rates using simulated data b
Asian Caucasian Both Asian Caucasian Both
n = 1028 n = 871 n = 1899 n = 1000 n = 1000 n = 1000
rs560426 3.84E-08 1.73E-03 1.12E-09 0.063 0.044 0.045
rs481931 6.93E-05 1.22E-03 3.04E-07 0.054 0.041 0.049
rs4147811 3.08E-05 6.16E-04 6.99E-08 0.057 0.043 0.053
rs2073485 1.24E-07 5.93E-01 4.02E-06 0.054 0.043 0.050
rs2013162 7.98E-07 2.98E-01 1.02E-05 0.052 0.038 0.061
rs861020 1.38E-04 7.34E-03 4.01E-06 0.055 0.047 0.056
rs10863790 7.31E-09 1.14E-01 2.01E-09 0.048 0.045 0.049
rs987525 8.53E-04 2.94E-12 1.74E-14 0.042 0.054 0.051
rs6072081 1.90E-06 2.10E-03 2.52E-08 0.045 0.053 0.040
rs6065259 1.00E-05 1.19E-02 7.57E-07 0.055 0.047 0.048
rs17820943 1.50E-07 5.70E-03 9.81E-09 0.038 0.059 0.051
rs13041247 8.80E-08 4.56E-03 4.92E-09 0.040 0.058 0.048
rs11696257 9.39E-08 5.07E-03 5.88E-09 0.041 0.057 0.053
rs6102085 8.67E-08 1.23E-01 5.00E-07 0.046 0.055 0.050
  1. aThe p values were based on the complete triads, which were used in the simulation study
  2. bBased on a per-comparison α-level of 0.05 and 2000 simulated studies