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Table 5 Disease-based enrichment analyses of the five datasets performed with MetaboAnalyst (SMPDB disease database), MBRole (HMDB disease database) and IPA® (in-house disease database) and MetaCore (based on MeSH and OMIM annotations). When the exact disease/condition of study was not obtained, a similar disease was selected

From: Evaluation and comparison of bioinformatic tools for the enrichment analysis of metabolomics data

Dataset Disease input Disease output Rank Input number metabolites Hits output P-value Adjusted p-value
MetaboAnalyst
 ST000091 Type 1 diabetes mellitus Diabetes mellitus MODY 20 8 2 3.40E-02 5.84E-01
 ST000383 Type 2 diabetes mellitus Diabetes mellitus MODY 4 27 4 8.60E-03 6.69E-01
Obesity Obesity 31 27 1 9.07E-02 8.83E-01
 MTBLS364 Smokers 81
 MTBLS424 Breast cancer Mammary tumour 30 22 2 4.08E-03 4.68E-02
 ST000284 Colorectal cancer Cervical/colon/ovarian cancer 46 42 1 8.47E-02 5.30E-01
MBRole
 ST000091 Type 1 diabetes mellitus 8
 ST000383 Type 2 diabetes mellitus Type 2 diabetes mellitus 8 27 3 1.16E-02 5.48E-02
Obesity Obesity 28 27 1 1.08E-01 1.48E-01
 MTBLS364 Smokers Lung Cancer 16 81 31 3.02E-02 9.25E-02
 MTBLS424 Breast cancer Lung Cancer 7 22 6 1.27E-04 1.09E-03
 ST000284 Colorectal cancer Colorectal cancer 44 42 1 5.19E-02 1.14E-01
IPA®
 ST000091 Type 1 diabetes mellitus 8
 ST000383 Type 2 diabetes mellitus Insulin resistance 21 27 3 6.10E-05 NA
Obesity Adipogenesis of fat 264 27 1 1.54E-02 NA
 MTBLS364 Smokers Cough 490 81 11 4.33E-02 NA
 MTBLS424 Breast cancer Gastric cancer 2 22 9 5.03E-11 NA
 ST000284 Colorectal cancer Colorectal cancer 3 42 11 2.31E-08 NA
MetaCore™
 ST000091 Type 1 diabetes mellitus Type 1 diabetes mellitus NA 8 0 NA NA
 ST000383 Type 2 diabetes mellitus Type 2 diabetes mellitus NA 27 7 NA NA
Obesity Obesity NA 27 1 NA NA
 MTBLS364 Smokers Respiratory disorders NA 81 1 NA NA
 MTBLS424 Breast cancer Breast neoplasms NA 22 0 NA NA
 ST000284 Colorectal cancer Colorectal neoplasms NA 42 13 NA NA
  1. Abbreviations: NA not available
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