|
Method
|
Rank
|
Rank
|
TPR in top
|
TPR in top
|
TPR in top
|
TPR in top
|
AUC
|
Rank difference
|
|---|
| |
median
|
average
|
1% (%)
|
5% (%)
|
10% (%)
|
30% (%)
| |
p-value
|
|---|
|
Genome-wide prioritizations
| |
|
Scuba
|
8.13
|
17.45 ± 22.33
|
10.4
|
41.7
|
58.3
|
79.2
|
0.83
|
-
|
|
MKL1class [12]
|
14.28
|
25.79 ± 26.96
|
2.1
|
27.1
|
45.8
|
66.7
|
0.74
|
1.2 ·10−5 *
|
|
ProDiGe [13]
|
7.89
|
18.40 ± 23.77
|
10.4
|
43.8
|
54.2
|
79.2
|
0.82
|
9.5 ·10−2
|
- Values refer to predictions on 48 gene-disease associations. Rank difference p-values were obtained using Wilcoxon signed rank tests comparing separately Scuba/MKL1class and Scuba/ProDiGe ranks differences. Asterisks indicate significance of the tests at a threshold of 0.05
- Italics indicates the top ranking score of each column
