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Table 4 Performances of Scuba, MKL1class and ProDiGe in the expanded unbiased setting involving seven multifactorial diseases

From: Scuba: scalable kernel-based gene prioritization

Method Rank Rank TPR in top TPR in top TPR in top TPR in top AUC Rank difference
  median average 1% (%) 5% (%) 10% (%) 30% (%)   p-value
Genome-wide prioritizations  
Scuba 8.13 17.45 ± 22.33 10.4 41.7 58.3 79.2 0.83 -
MKL1class [12] 14.28 25.79 ± 26.96 2.1 27.1 45.8 66.7 0.74 1.2 ·10−5 *
ProDiGe [13] 7.89 18.40 ± 23.77 10.4 43.8 54.2 79.2 0.82 9.5 ·10−2
  1. Values refer to predictions on 48 gene-disease associations. Rank difference p-values were obtained using Wilcoxon signed rank tests comparing separately Scuba/MKL1class and Scuba/ProDiGe ranks differences. Asterisks indicate significance of the tests at a threshold of 0.05
  2. Italics indicates the top ranking score of each column