From: GenIO: a phenotype-genotype analysis web server for clinical genomics of rare diseases
Feature \ Web servers | PhenIX | eXtasy | OMIM Explorer | Phen-Gen | wAnnovar | GenIO |
---|---|---|---|---|---|---|
Year of last update | 2014 | 2013 | 2016 | 2013 | 2015 | 2017 |
Simple Input interface | Yes | Yes | No | Yes | Yes | Yes |
Acceptance of VCF files | Yes | Yes | Yes | Yes | Yes | Yes |
Phenotype (HPO terms) | Yes | Yes | Yes | IDs only | Yes | Yes |
Phenotype (OMIM terms) | No | No | Yes | No | Yes | Yes |
List of genes of interest to analyze | No | No | Yes | No | No | Yes |
Customizable Rareness of the condition | Yes | No | Yes | Yes | Yes | Yes |
Fast responsive interface | Yes | Yes | No | Yes | Yes | Yes |
No need of extra files to run | Yes | Yes | Yes | No | Yes | Yes |
Trio datasets | No | No | No | Yes | No | No |
Freeform text input | No | No | Yes | No | No | No |
Email notification | No | Yes | No | Yes | Yes | Yes |
Dominant and Recessive in single run | Yes | No | Yes | No | Yes | Yes |
Can be used by a medical practitioner | Yes | No | Yes | No | Yes | Yes |
Output interface with results | Yes | No | Yes | No | Yes | Yes |
Simple Output interface | Yes | – | No | – | Yes | Yes |
ACMG-AMP Classification | No | No | No | No | No | Yes |
M-CAP Classification | No | No | No | No | No | Yes |
ClinVar Classification | Top 20 only | No | No | No | Yes | Yes |
ACMG Secondary findings | No | No | No | No | No | Yes |
Full VCF annotation | No | No | No | No | Yes | Yes |
Handful set of candidate variants | Yes | No | Yes | Yes | Yes | Yes |
Session saving | No | Yes | Yes | Yes | Yes | Yes |
Phenotype suggestion | No | No | Yes | No | No | No |
Secure server (https) | No | No | No | No | No | Yes |
Multi-nucleotide variants | Yes | No | Yes | Yes | Yes | Yes |