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Table 8 Mean and standard deviation (in parentheses) measures of F1 score, classification accuracy, precision, recall, MCC and ROC-AUC obtained on the test set at the local surface patch level using the corresponding best SVM model

From: Exploring the potential of 3D Zernike descriptors and SVM for protein–protein interface prediction

Protein complex Receptor Bound F1 score Accuracy Precision Recall MCC ROC-AUC
class ligand unbound       
A r b 0.272 (0.101) 0.862 (0.033) 0.166 (0.073) 0.917 (0.056) 0.346 (0.346) 0.954 (0.019)
   u 0.274 (0.121) 0.876 (0.026) 0.169 (0.086) 0.883 (0.084) 0.341 (0.341) 0.939 (0.044)
  l b 0.093 (0.096) 0.811 (0.045) 0.067 (0.071) 0.182 (0.152) 0.019 (0.019) 0.538 (0.154)
   u 0.097 (0.055) 0.059 (0.030) 0.052 (0.030) 0.987 (0.014) -0.016 (-0.016) 0.473 (0.053)
AB r b 0.230 (0.104) 0.910 (0.023) 0.161 (0.080) 0.590 (0.176) 0.256 (0.256) 0.890 (0.032)
   u 0.228 (0.116) 0.913 (0.020) 0.156 (0.073) 0.546 (0.284) 0.250 (0.250) 0.845 (0.112)
  l b 0.183 (0.101) 0.653 (0.170) 0.112 (0.069) 0.553 (0.139) 0.110 (0.110) 0.655 (0.119)
   u 0.115 (0.083) 0.246 (0.093) 0.063 (0.049) 0.931 (0.086) 0.071 (0.071) 0.667 (0.180)
EI r b 0.156 (0.073) 0.604 (0.084) 0.089 (0.044) 0.770 (0.214) 0.158 (0.158) 0.764 (0.130)
   u 0.148 (0.070) 0.645 (0.070) 0.087 (0.045) 0.705 (0.243) 0.146 (0.146) 0.747 (0.137)
  l b 0.253 (0.101) 0.535 (0.119) 0.154 (0.068) 0.793 (0.233) 0.167 (0.167) 0.725 (0.177)
   u 0.203 (0.104) 0.360 (0.095) 0.118 (0.065) 0.865 (0.192) 0.086 (0.086) 0.673 (0.150)
ER r b 0.145 (0.077) 0.733 (0.043) 0.089 (0.060) 0.580 (0.186) 0.136 (0.136) 0.734 (0.096)
   u 0.109 (0.063) 0.747 (0.055) 0.065 (0.044) 0.465 (0.163) 0.092 (0.092) 0.663 (0.092)
  l b 0.214 (0.151) 0.494 (0.102) 0.136 (0.127) 0.851 (0.145) 0.167 (0.167) 0.774 (0.147)
   u 0.137 (0.101) 0.087 (0.063) 0.077 (0.062) 0.998 (0.005) 0.019 (0.019) 0.685 (0.144)
ES r b 0.031 (0.026) 0.954 (0.020) 0.086 (0.088) 0.023 (0.022) 0.023 (0.023) 0.712 (0.077)
   u 0.121 (0.108) 0.861 (0.040) 0.090 (0.087) 0.281 (0.193) 0.096 (0.096) 0.709 (0.153)
  l b 0.150 (0.070) 0.665 (0.057) 0.087 (0.043) 0.665 (0.193) 0.142 (0.142) 0.703 (0.144)
   u 0.169 (0.110) 0.636 (0.074) 0.102 (0.077) 0.670 (0.163) 0.148 (0.148) 0.720 (0.140)
OG r b 0.184 (0.110) 0.704 (0.039) 0.113 (0.072) 0.552 (0.203) 0.145 (0.145) 0.700 (0.078)
   u 0.144 (0.114) 0.805 (0.031) 0.103 (0.097) 0.340 (0.253) 0.100 (0.100) 0.631 (0.158)
  l b 0.127 (0.031) 0.373 (0.071) 0.069 (0.017) 0.927 (0.080) 0.125 (0.125) 0.722 (0.069)
   u 0.108 (0.034) 0.089 (0.028) 0.058 (0.019) 0.996 (0.007) 0.037 (0.037) 0.653 (0.119)
OR r b 0.121 (0.079) 0.662 (0.068) 0.073 (0.053) 0.558 (0.203) 0.093 (0.093) 0.659 (0.109)
   u 0.103 (0.087) 0.115 (0.047) 0.057 (0.052) 0.968 (0.032) 0.024 (0.024) 0.626 (0.162)
  l b 0.172 (0.099) 0.269 (0.063) 0.098 (0.063) 0.980 (0.026) 0.120 (0.120) 0.723 (0.085)
   u 0.190 (0.100) 0.592 (0.082) 0.153 (0.171) 0.593 (0.183) 0.095 (0.095) 0.658 (0.119)
OX r b 0.108 (0.088) 0.677 (0.081) 0.063 (0.057) 0.555 (0.221) 0.089 (0.089) 0.665 (0.154)
   u 0.081 (0.054) 0.670 (0.087) 0.045 (0.032) 0.490 (0.221) 0.056 (0.056) 0.614 (0.146)
  l b 0.168 (0.070) 0.369 (0.094) 0.095 (0.043) 0.896 (0.109) 0.120 (0.120) 0.720 (0.113)
   u 0.151 (0.066) 0.352 (0.061) 0.085 (0.041) 0.846 (0.092) 0.077 (0.077) 0.668 (0.110)