Fig. 3

Oasis 2′ (QC) outlier detection: To assess the QC of Oasis 2 and its biological relevance, sRNA Psoriasis data (demo dataset) was analyzed. PCA sample distances of psoriasis (green) and control (blue) is shown. (a) PCA of psoriasis and control samples showing a potentially mis-annotated (SRR330866_PP) and an outlier sample (SRR330860_PP). (b) PCA of psoriasis and control samples without misclassified/outlier samples. Removal of these two samples increased the number of significantly (adjusted p-value < 0.1) DE miRNAs from 195 to 256 cases and increased the AUC from 0.9 to 1 in the classification module, providing strong evidence for the utility of Oasis 2’ QC plots