Fig. 4
From: Pathway-based approach using hierarchical components of rare variants to analyze multiple phenotypes
Comparison of simulation results of statistical power from various methods of multiple testing adjustment. The value of w = 0.1. Red and green bars represent results obtained by the PHARAOH-multi (“P_M”, using joint testing) and p-value aggregation (“P_K”) methods, respectively. Teal and purple bars represent the aSPU and MARV methods, respectively. Powers were calculated by the proportion of the causal pathway’s q-value, obtained by the Benjamini-Hochberg procedure (< 0.05). Paired t-test p-values are 7.3 × 10− 7 and 4.2 × 10− 6 for P_M vs. aSPU and P_M vs. MARV, respectively