Fig. 6
From: An interpretable framework for clustering single-cell RNA-Seq datasets
Exploratory analysis on PBMC dataset. a After gene selection and removal of cells with less than 50 counts across all genes, DendroSplit generates clusters for Zheng et al.’s remaining dataset of 17426 cells, 908 features (genes) from fresh peripheral blood mononuclear cells (PBMCs) [21]. Gene expression is quantified using UMI counts. The split and merge thresholds are 200 and 100, respectively, and the analysis takes 119.97 seconds to run. b 5 of the 15 recorded valid splits are shown along with the expression levels of the top 4 genes used for validating each split. The reported runtimes include computation of the pairwise distance matrices