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Fig. 7 | BMC Bioinformatics

Fig. 7

From: An interpretable framework for clustering single-cell RNA-Seq datasets

Fig. 7

Split threshold sweeping. Since DendroSplit saves all relevant information at each valid split (e.g. p-values from Welch’s t-tests and IDs of cells being compared), we can run the method with a small split threshold to gather information about several potential splits. From this information, we can generate the labels we would have obtained after the split step had we run the algorithm with a larger split threshold. a For the 704×13473 Kolodziejczyk et al. [5] dataset, running DendroSplit using a split threshold of 2 takes 37.63 seconds, and generating a set of new labels takes 0.032 seconds. b For the 3005×1202 Zeisel et al. dataset, running DendroSplit using a split threshold of 2 takes 13.48 seconds, and generating new labels takes 0.403 seconds. For both datasets, the DendroSplit runtimes include computation of the pairwise distance matrices

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