Fig. 5
From: Comparative assessment of strategies to identify similar ligand-binding pockets in proteins
Characteristics of local alignments constructed by pocket matching algorithms for the APoc dataset. Top panel shows the correlation between the global structure similarity score, TM-score, and the local alignment score, (a) PS-score by APoc, (b) Match score by SiteEngine, and (c) GA-score by G-LoSA. Bottom panel shows the correlation between local alignment scores reported by individual pocket matching algorithms, (d) APoc, (e) SiteEngine, and (f) G-LoSA, and Kendall Ï„ measuring the degree of the ordinal association of binding site alignments. Dotted lines mark thresholds for statistically significant alignments