Fig. 1

Deformation of the TMA grid. An ideal TMA (left top) has tissue cores perfectly aligned in vertical and horizontal directions with equal spacing according to a regular square grid (left bottom). The manufactured TMA (right top) is subjected to a non-linear deformation of the TMA grid resulting to a distorted grid (right bottom). We aim at de-arraying the observed TMA by estimating the deformation which transforms the ideal grid into the distorted grid