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Table 1 Literature review of cyclohexanone metabolite associated diseases

From: Robust volcano plot: identification of differential metabolites in the presence of outliers

Authors Disease Title of the paper Journal name
Westhoff et al., 2010 [35] Lung cancer Differentiation of chronic obstructive pulmonary disease (COPD) including lung cancer from healthy control group by breath analysis using ion mobility spectrometry International Journal for Ion Mobility Spectrometry
Wei et al., 2012 [36] Prostate cancer Effects of cyclohexanone analogues of curcumin on growth, apoptosis and NF-κB activity in PC-3 human prostate cancer cells Oncology letters
Leung et al. 2012 [37] Breast cancer Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells Investigational new drugs
Wang et al., 2014 [26] Breast cancer Volatile Organic Metabolites Identify Patients with Breast Cancer, Cyclomastopathy, and Mammary Gland Fibroma Scientific Report (Nature)
Mochalski et al., 2014 [38] Renal disease Blood and breath profiles of volatile organic compounds in patients with end-stage renal disease BMC Nephrology
Liu et al., 2014 [39] Lung cancer Investigation of volatile organic metabolites in lung cancer pleural effusions by solid-phase microextraction and gas chromatography/mass spectrometry Journal of Chromatography
Silva et al., 2017 [40] Breast cancer Volatile metabolomic signature of human breast cancer cell lines Scientific Report (Nature)