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Fig. 6 | BMC Bioinformatics

Fig. 6

From: Generation and comparative genomics of synthetic dengue viruses

Fig. 6

Results of AG129 mouse model study. a. Percentage of survival of AG129 mice infected with wild-type and synthetic DENV-2 (p-value < 0.001 for 12 dpi and furhter, as compared with sham controls). b. Mean weight change (%) of AG129 mice infected with different DENV-2 variants. c Virus titers from serum collected 3 dpi from infected AG129 mice (**p-value < 0.01, *p-value < 0.05, as compared with sham controls). d 50% plaque reduction neutralization titers (PRNT50) from serum taken 14 dpi (***p-value < 0.001, as compared with sham controls). Note that there were not sufficient quantities of serum for 5 samples: 2 from group 1(infected with WT variant), 1 from group 2 (infected with synthetic variant) and 2 from control group for quantification of neutralizing Ab

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