From: Generation and comparative genomics of synthetic dengue viruses
Animals: Male and female AG129 mice | Duration of experiment: 28Â days | ||||
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Virus route: Intraperitoneal injection | Volume: 0.2Â ml | ||||
 | Toxicity controls | Infected, treated | |||
Treatment | Virus titer (ge/μg RNA)a | PRNT50 titer (GM ± SD)b | Alive / total | Virus titer (ge/μg RNA) | PRNT50 titer (GM ± SD)b |
DENV-2 WT | – | – | 4/8 | 1.3 ± 1.4* | 1.5 ± 0.7 |
DENV-2 synth | – | – | 2/8 | 2.1 ± 0.3** | 2.8 ± 0.2*** |
Vehicle control | 0.0 ± 0.0 | 1.0 ± 0.0 | – | – | – |