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Fig. 1 | BMC Bioinformatics

Fig. 1

From: Computer simulations of the signalling network in FLT3 +-acute myeloid leukaemia – indications for an optimal dosage of inhibitors against FLT3 and CDK6

Fig. 1

The interaction network of FLT3. FLT3 is represented in yellow and through different nodes it transduces the signal to proliferation and apoptosis, the network’s end-points that contribute to the development of AML (red nodes). Blue nodes represent potential candidates for combined inhibition therapy. Note that the two end-points yield different consequences: proliferation leads to tumour growth, whereas apoptosis limits the growth (and thus LOA leads to tumour growth)

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BMC Bioinformatics

ISSN: 1471-2105

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