Table 1 Correspondence (number of cases) between the HER2 classification of individuals by IHC level and status, and FISH, obtained from the BRCA clinical data (individuals with non-concordance for HER2 classification by different testing (‘positive’ vs. ‘negative’) are highlighted in bold)
From: Ensemble outlier detection and gene selection in triple-negative breast cancer data
HER2 (IHC)status | |||||||
|---|---|---|---|---|---|---|---|
‘’ | Equivocal | Indeterminate | Negative | Positive | Total | ||
HER2 (IHC) level | ‘’ | 176 | 7 | 6 | 241 | 41 | 471 |
0 (negative) | 0 | 0 | 0 | 60 | 0 | 60 | |
1+ (negative) | 0 | 4 | 1 | 255 | 11 | 271 | |
2+ (indeterminate) | 0 | 166 | 4 | 1 | 27 | 198 | |
3+ (positive) | 1 | 1 | 1 | 2 | 85 | 90 | |
Total | 177 | 178 | 12 | 559 | 164 | 1090 | |
HER2 (FISH) | ‘’ | 115 | 18 | 4 | 432 | 104 | 673 |
equivocal | 0 | 3 | 0 | 0 | 2 | 5 | |
indeterminate | 0 | 0 | 0 | 3 | 1 | 4 | |
negative | 53 | 138 | 6 | 121 | 12 | 330 | |
positive | 9 | 19 | 2 | 3 | 45 | 78 | |
Total | 177 | 178 | 12 | 559 | 164 | 1090 | |