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Table 1 The 10 highest affinity peptides found with GAMPMS compared with the native α-CTx MII peptide for binding with α3β2-nAChR

From: SPIDR: small-molecule peptide-influenced drug repurposing

Peptidea Gbindb
GCCS Y PVC YWTN SNLC −21.07
GCCS Y PVCH WQS SN F C − 20.91
GCCS Y PVC YWQS SN V C −20.91
GCCS Y PVCH WSS SN F C −20.88
GCCS Y PVCH WSS SN W C −20.79
GCCS Y PVC SWKS SN F C −20.74
GCCS Y PVCH WYS SN V C −20.73
GCCS Y PVC KWSN SN G C −20.71
GCCS Y PVC NWSS SN W C −20.68
GCCS Y PVCH WKS SN G C −20.66
GCCSNPVCHLEHSNLC (MII) −12.38
  1. aMutations in bold type; bkcal/mol, estimated in AutoDock