Skip to main content

Table 2 Results of TP53-dependent analysis of genomic and clinical characteristics

From: Integrative analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB)

(a)
  Patients Events 5-year survival rate [%] Median survival 95% CI
TP53 mutant 3772 1237 47.4 1670 [1526; 1818]
TP53 non-mutant 5672 1128 66.9 3736 [3262; 4267]
(b)
  Patients CNAs [Mb]
TP53 mutant 133 74.5
TP53 non-mutant 246 50.5
(c)
   TP53 ATM
VarType All Mutant [%] (n = 320) Non-mutant [%] (n = 265) p-value Mutant [%] (n = 49) Non-mutant [%] (n = 536) p-value
A > C or T > G 3.5 3.3 3.6 <  0.0001 3.9 3.4 0.2160
A > G or T > C 9.9 9.2 10.7 <  0.0001 9.6 9.9 0.7695
A > T or T > A 8.1 8.4 7.8 0.0005 8.6 8.1 0.4584
C > G or G > C 13.6 13.9 13.1 <  0.0001 13.2 13.6 0.3790
C > T or G > A 32.7 30.0 36.0 <  0.0001 28.6 33.0 0.5121
G > T or C > A 32.3 35.2 28.8 0.0001 36.0 32.0 0.4940