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Table 2 Results of TP53-dependent analysis of genomic and clinical characteristics

From: Integrative analysis and machine learning on cancer genomics data using the Cancer Systems Biology Database (CancerSysDB)

(a)

 

Patients

Events

5-year survival rate [%]

Median survival

95% CI

TP53 mutant

3772

1237

47.4

1670

[1526; 1818]

TP53 non-mutant

5672

1128

66.9

3736

[3262; 4267]

(b)

 

Patients

CNAs [Mb]

TP53 mutant

133

74.5

TP53 non-mutant

246

50.5

(c)

  

TP53

ATM

VarType

All

Mutant [%] (n = 320)

Non-mutant [%] (n = 265)

p-value

Mutant [%] (n = 49)

Non-mutant [%] (n = 536)

p-value

A > C or T > G

3.5

3.3

3.6

<  0.0001

3.9

3.4

0.2160

A > G or T > C

9.9

9.2

10.7

<  0.0001

9.6

9.9

0.7695

A > T or T > A

8.1

8.4

7.8

0.0005

8.6

8.1

0.4584

C > G or G > C

13.6

13.9

13.1

<  0.0001

13.2

13.6

0.3790

C > T or G > A

32.7

30.0

36.0

<  0.0001

28.6

33.0

0.5121

G > T or C > A

32.3

35.2

28.8

0.0001

36.0

32.0

0.4940

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BMC Bioinformatics

ISSN: 1471-2105

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