Fig. 3

Multi-omic pattern operon compression is shown in Figure a. The elements that belong to the same operon (e₂- e₃- e₄) are merged to the more frequent multi-omic value: in this case the low one (blue-head cylinder). The path extension is shown in Figure b. In this case, the MLS is modified searching an alternative path, on the global metabolic network, that links two nodes associated to two not oscillating pattern adjacent multi-omics (i.e the multi-omics in the positions e₂- e₃ and e₃- e₄). The multi-omic path, chosen from among all the alternative paths on the whole metabolic network, is the shortest path with the most oscillating multi-omics. (i.e in the path extension between e₃- e₄ is chosen the path p₃- p₅- p₄ (violet dotted lines) and not the path p₃- p₈- p₄