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Fig. 8 | BMC Bioinformatics

Fig. 8

From: A study on multi-omic oscillations in Escherichia coli metabolic networks

Fig. 8

An MLS with high reciprocal influences (RI) but with a low number of oscillating multi-omics is shown in (1). On this MLS, due to the effect of the treatments t, an oscillating multi-omic circuit is activated (orange links in the yellow circle) and is deactivated another one. The MLS become combined due to the effect of t because both the pattern and the pathway show oscillating multi-omics at the same time. Opposite, in (2), the effect of treatments activate and deactivate the same oscillating multi-omic circuits, but, due to the changed pattern elements order, only the pathway shows oscillating multi-omics, instead the pattern shows a low number of oscillations. In this case, the structures are defined competitor. The change of only two multi-omic values (p3 and p5) on the overall pathway and on the pattern (e3 and e5) affect the whole recurring multi-omic pattern and its MLS

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