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Fig. 3 | BMC Bioinformatics

Fig. 3

From: NetControl4BioMed: a pipeline for biomedical data acquisition and analysis of network controllability

Fig. 3

A visualization of the generated network from the pipeline. Proteins PIK3R3, PIK3CB, PIK3R1, PIK3CG, PIK3CD, PIK3CA, PIK3R5 and PIK3R2 are promoted/activated by ERBB3. They promote/activate AKT1, AKT2, AKT3 and MTOR and inhibit AKT1, AKT2 and AKT3. Proteins PIK3R3, PIK3CB, PIK3R1, PIK3CG, PIK3CD, PIK3CA, PIK3R5 and PIK3R2 have no interactions between each other. NRG1 controls ERBB3 and AKT1 controls MTOR. The colors have the following meaning: “seed nodes” are shown in green circle (NRG1, ERBB3, MTOR), “driven drug-target nodes” are represented as aqua color (AKT1), “controlled from drug-target nodes” are shown in purple color (MTOR), “driven non-drug-target nodes” are shown in red color (NRG1) and “controlled from non-drug-target nodes” are shown in orange yellow (ERBB3)

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