Fig. 1

Wiring diagram of the EColiCore2 model. Metabolic network is modified (adding reverse reactions and cofactors) from Hädicke et al. [16]. In the map, reaction names are labeled in blue and placed next to the corresponding edge. The external environment is represented by a dashed contour, the cell is delimited by a solid contour. Significant reactions emerging from the Kolmogorov-Smirnov test described in section Results are labeled in red