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Table 6 The performances of 6 joint tests based on EPIC data GSE107080

From: Robust joint score tests in the application of DNA methylation data analysis

Test nSig nValidation nTV pTV(%) nFV pFV(%)
JointLRT 51994 19806 5652 28.5 14154 71.5
KS 10 3 1 33.3 2 66.7
AW 12 5 2 40.0 3 60.0
iAW.Lev 709 201 89 44.3 112 55.7
iAW.BF 22 7 4 57.1 3 42.9
iAW.TM 22 9 5 55.6 4 44.4
  1. nSig: the number of significant CpG sites detected in the training set of GSE107080 based on FDR adjusted p-value < 0.05;
  2. nValidation: the number of validated CpG sites in the validation set of GSE107080 based on unadjusted p-value < 0.05;
  3. nTV: the number of truly validated CpG sites with the same difference directions in means and variances between the two groups;
  4. pTV: \(=\frac {nTV}{nValidation}\), the proportion of significant CpG sites detected in the training set and truly validated in the validation set;
  5. nFV: the number of falsely validated CpG sites in validation set with inconsistent difference direction in means or variances between the two groups;
  6. pFV: \(=\frac {nFV}{nValidation}\), the proportion of significant CpG sites detected in the training set but falsely validated in the validation set