Skip to main content

Table 6 The performances of 6 joint tests based on EPIC data GSE107080

From: Robust joint score tests in the application of DNA methylation data analysis

Test

nSig

nValidation

nTV

pTV(%)

nFV

pFV(%)

JointLRT

51994

19806

5652

28.5

14154

71.5

KS

10

3

1

33.3

2

66.7

AW

12

5

2

40.0

3

60.0

iAW.Lev

709

201

89

44.3

112

55.7

iAW.BF

22

7

4

57.1

3

42.9

iAW.TM

22

9

5

55.6

4

44.4

  1. nSig: the number of significant CpG sites detected in the training set of GSE107080 based on FDR adjusted p-value < 0.05;
  2. nValidation: the number of validated CpG sites in the validation set of GSE107080 based on unadjusted p-value < 0.05;
  3. nTV: the number of truly validated CpG sites with the same difference directions in means and variances between the two groups;
  4. pTV: \(=\frac {nTV}{nValidation}\), the proportion of significant CpG sites detected in the training set and truly validated in the validation set;
  5. nFV: the number of falsely validated CpG sites in validation set with inconsistent difference direction in means or variances between the two groups;
  6. pFV: \(=\frac {nFV}{nValidation}\), the proportion of significant CpG sites detected in the training set but falsely validated in the validation set