Fig. 5

Gene regulatory networks for HeteroPath tissue-specific pathways a The heat map shows the normalized mRNA expression level in Brain, Lung, and Heart endothelial cells for the heterogeneous genes of the Wnt signaling pathway. b Wnt signaling gene regulatory network including upregulated transcription factors which bind motifs in the promoter region of brain-specific heterogeneous elements. c The heat map shows the normalized mRNA expression level in hippocampal, cingulate cortex, and amygdala neurons for the heterogeneous genes of the oxidative phosphorylation pathway d Oxidative phosphorylation gene regulatory network including upregulated transcription factors which bind motifs in the promoter region of hippocampal-specific heterogeneous elements