Table 5 Gene ontology analysis of the genes appearing in the independent embeddings of the triangle pattern in the three disease networks with publications, and the diseases associated with the ontology terms
From: ProMotE: an efficient algorithm for counting independent motifs in uncertain network topologies
Category | GO ID | Function name | p-value | Reference | Disease |
|---|---|---|---|---|---|
| Â | 0006120 | mitochondrial electron transport, NADH to ubiquinone | 2.65E-58 | Perier and Vila [36] | PD |
| Â | 0042776 | mitochondrial ATP synthesis coupled proton transport | 1.43E-20 | VanDuyn et al. [37] | AD,PD |
Biological | 0006123 | mitochondrial electron transport, cytochrome c to oxygen | 4.66E-20 | Fiskum et al. [38] | PD |
Process | 0006122 | mitochondrial electron transport, ubiquinol to cytochrome c | 5.13E-19 | Kim et al. [39] | AD |
| Â | 0006099 | tricarboxylic acid cycle | 2.43E-02 | Shi et al. [40] | AD |
| Â | 0003954 | NADH dehydrogenase activity | 9.19E-53 | Zubenko et al. [41] | AD |
| Â | 0004129 | cytochrome-c oxidase activity | 1.4E-18 | Cardoso et al. [42] | AD |
Molecular | 0008121 | ubiquinol-cytochrome-c reductase activity | 9.53E-14 | Liang et al. [43] | AD |
Function | 0000104 | succinate dehydrogenase activity | 6.42E-06 | Fattoretti et al. [44] | AD,HD |
| Â | 0048038 | quinone binding | 8.33E-04 | Wang et al. [45] | AD,PD |
| Â | 0051537 | 2 iron, 2 sulfur cluster binding | 4.56E-03 | Isaya [46] | PD |