Normalization Method | Gene length correction | Distribution per sample | Influence of RIN on correlation | Intersample correlation | Intrasample correlation |
---|---|---|---|---|---|
RLE (DESeq2) | no | bimodal | no bias | ++ | + |
TMM (edgeR) | no | bimodal | no bias | ++ | + |
TPM | yes | normal | bias | – | ++ |
GeTMM | yes | normal | no bias | ++ | ++ |