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Table 2 Summary of results

From: Gene length corrected trimmed mean of M-values (GeTMM) processing of RNA-seq data performs similarly in intersample analyses while improving intrasample comparisons

Normalization Method

Gene length correction

Distribution per sample

Influence of RIN on correlation

Intersample correlation

Intrasample correlation

RLE (DESeq2)

no

bimodal

no bias

++

+

TMM (edgeR)

no

bimodal

no bias

++

+

TPM

yes

normal

bias

–

++

GeTMM

yes

normal

no bias

++

++

  1. A ‘-’ indicates a relative poor performance for the given criterion, and increasing performance is indicated by ‘+’ and ‘++’