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Table 2 Summary of results

From: Gene length corrected trimmed mean of M-values (GeTMM) processing of RNA-seq data performs similarly in intersample analyses while improving intrasample comparisons

Normalization Method Gene length correction Distribution per sample Influence of RIN on correlation Intersample correlation Intrasample correlation
RLE (DESeq2) no bimodal no bias ++ +
TMM (edgeR) no bimodal no bias ++ +
TPM yes normal bias ++
GeTMM yes normal no bias ++ ++
  1. A ‘-’ indicates a relative poor performance for the given criterion, and increasing performance is indicated by ‘+’ and ‘++’