Fig. 3
From: npInv: accurate detection and genotyping of inversions using long read sub-alignment
Performance comparison for npInv, Lumpy and Sniffles at three type of inversions. We simulated a diploid human chromosome 21 with three types of inversions: non-allelic homologous recombination (NAHR), non-homologous end joining (NHEJ) with size less than 4 kb and NHEJ with the size between 4 kb to 1 Mb (n = 61, 100 and 100, respectively). Software Lumpy [16], Sniffles [17] and npInv were applied to the above datasets. (a, b, c) and (d, e, f) showed Positive predicted value (PPV) and sensitivity for each method, respectively. (g) showed Genotype Consistency(GC) for npInv. Lumpy did not detect NAHR inversion and genotype information is not available for Lumpy or Sniffles