Fig. 4
From: BROCKMAN: deciphering variance in epigenomic regulators by k-mer factorization
PCs represent TF variation. a Partitioning cells by treatment. Shown is a projection of treated (shades of blue) and untreated (shades of pink) K562 cells onto PC 3 and 5 from BROCKMAN analysis of only K562 cells. b Identification of TFs associated with specific PCs. Scatter plot shows the PC weights for each 8-mer (dot) for PC 3 (x axis) and PC5 (y axis). Colored dots: k-mers recognized by JUNB (red), JUND (blue), and both (green), with consensus JUN 7-mer shown as a pink star, as defined using PBM 8-mer Z-scores [23]; the legend (bottom right) shows PWMs derived from the same PBM 8-mer Z-scores. Side graphs show the Log2 fold enrichment of JUNB- and JUND-bound k-mers amongst lowly-weighted PC k-mer weights for PC 3 (bottom) and PC 5 (right)