Fig. 4From: Effective normalization for copy number variation in Hi-C dataCNV-adjusted normalization of cancer Hi-C data. a. Hi-C contact maps of the four first chromosomes of our highly rearranged simulated data, together with the 1D signal of all, cis and trans data. Regions in red and green correspond to simulated gains and losses. b. Block-average error matrix of simulated ICE and CAIC Hi-C data. The CAIC efficiently removed the CNV effect, whereas the ICE normalization does not allow to correct for its effectBack to article page