Fig. 6
From: Effective normalization for copy number variation in Hi-C data
Duplication in capture-Hi-C and normalization. a. 1D profiles of capture-Hi-C wild-type sample (WT), with intra-TAD duplication (dup-S) or with inter-TAD (dup-L) duplication [10]. As expected, the duplication samples are characterized by twice more contacts at the duplicated sites. b. Raw and ICE normalized contact maps of WT sample. c. Normalization of the dup-S sample with the ICE and LOIC methods. The duplication effect is visualized by subtracting the normalized WT and dup-S contact maps. d. Same approach applied to the dup-L sample