Fig. 7
From: Effective normalization for copy number variation in Hi-C data
Detection of chromosome compartments. a. Genome-wide enrichment of ChIP-seq histone marks in open (A) or closed (B) compartments. Open compartments are enriched in open-chromatin marks, whereas closed compartments are enriched in repressive marks. The results are concordant genome-wide, whatever the normalization method applied. b. Histone marks enrichment on chromosome 8 of MCF7 sample. On this chromosome, the copy number has a strong impact on the compartment calling. c. Results of the compartment calling for the chromosome 8 of MCF7 sample (first principal component), together with normalized ChIP-seq tracks. Open chromatin domains are in red. Closed domains in blue