Skip to main content
Fig. 2 | BMC Bioinformatics

Fig. 2

From: Alternative empirical Bayes models for adjusting for batch effects in genomic studies

Fig. 2

Distribution of gene-wise variance estimates from each batch in the bladder cancer data. Batch 3 and batch 4 have smaller sample size than the other batches, thus their variance estimates are impacted more by outlying samples. Mean/variance ComBat brings all estimates to the same levels, over correcting the variance estimates in batches 3 and 4. This leads to unwanted, less variable gene expression (see Additional file 1: Figure S1). Mean-only ComBat does not affect or overcorrect the variance estimates

Back to article page