From: Alternative empirical Bayes models for adjusting for batch effects in genomic studies
 |  | Sample-wise tests | Gene-wise tests | ||||||
---|---|---|---|---|---|---|---|---|---|
Dataset | ComBat | Mean | Variance | Skewness | Kurtosis | Mean | Variance | Skewness | Kurtosis |
Bladder cancer | None | <0.0001 | 0.6495 | 0.0539 | 0.3149 | <0.0001 | 0.3353 | <0.0001 | 0.0012 |
 | Mean-only | 0.9998 | 0.9557 | 0.1496 | 0.6236 | 0.2011 | 0.3618 | <0.0001 | 0.0012 |
 | Mean/variance | 1 | 0.8989 | 0.1826 | 0.2737 | 0.2538 | 0.9816 | <0.0001 | 0.0012 |
Nitric oxide | None | 0.1007 | 0.3565 | 0.1009 | 0.866 | <0.0001 | 0.0005 | <0.0001 | 0.9887 |
 | Mean-only | 0.9997 | 0.577 | 0.9838 | 0.9485 | 0.4595 | 0.0042 | <0.0001 | 0.9887 |
 | Mean/variance | 1 | 0.982 | 0.9847 | 0.7013 | 0.7245 | 0.6219 | <0.0001 | 0.9791 |
Oncogenic signature | None | 0.0011 | <0.0001 | 0.0001 | 0.0235 | <0.0001 | 0.0001 | <0.0001 | 0.5711 |
 | Mean/variance | 1 | 0.7486 | 0.5553 | 0.9202 | 0.0363 | 0.8919 | <0.0001 | 0.5711 |
Lung cancer | None | <0.0001 | <0.0001 | <0.0001 | <0.0001 | <0.0001 | 0.0106 | <0.0001 | 0.4853 |
 | Mean/variance | 1 | 0.9872 | 0.0003 | 0.9612 | 0.0016 | 0.9971 | <0.0001 | 0.4853 |